Effect of rescue or adjunctive percutaneous coronary intervention of the culprit artery after fibrinolytic administration on epicardial flow in nonculprit arteries.
نویسندگان
چکیده
We hypothesized that blood flow in noninfarct arteries would improve after percutaneous coronary intervention of the culprit artery in the setting of ST-elevation myocardial infarction (STEMI). The corrected Thrombolysis In Myocardial Infarction (TIMI) frame count was measured in 94 patients (102 arteries) enrolled in the INTEGRITI, ENTIRE, and FASTER trials of reduced dose fibrinolytic and glycoprotein IIb/IIIa inhibition. The corrected TIMI frame count in nonculprit arteries improved by 3.4 +/- 13.4 frames after percutaneous coronary intervention but remained significantly slower than flow in normal arteries.
منابع مشابه
Impaired coronary blood flow in nonculprit arteries in the setting of acute myocardial infarction. The TIMI Study Group. Thrombolysis in myocardial infarction.
OBJECTIVES AND BACKGROUND While attention has focused on coronary blood flow in the culprit artery in acute myocardia infarction (MI), flow in the nonculprit artery has not been studied widely, in part because it has been assumed to be normal. We hypothesized that slower flow in culprit arteries, larger territories infarcted and hemodynamic perturbations may be associated with slow flow in nonc...
متن کاملRelationship of the TIMI myocardial perfusion grades, flow grades, frame count, and percutaneous coronary intervention to long-term outcomes after thrombolytic administration in acute myocardial infarction.
BACKGROUND Although 90-minute TIMI flow grades (TFGs), corrected TIMI frame counts (CTFCs), and TIMI myocardial perfusion grades (TMPGs) have been associated with 30-day outcomes, we hypothesized that these indices would be related to long-term outcomes after thrombolytic administration. METHODS AND RESULTS As a substudy of the TIMI 10B trial (tissue plasminogen activator versus tenecteplase)...
متن کاملIntracoronary administration of abciximab acutely increases flow through culprit vessels of patients with acute coronary syndromes undergoing percutaneous coronary intervention.
Acutely Increases Flow Through Culprit Vessels of Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention To the Editor: We read with interest the article by Wöhrle et al1 reporting the reduction of major coronary events with the intracoronary compared with the intravenous administration of abciximab in patients with acute coronary syndromes undergoing percutaneous ...
متن کاملAssociation of a negative residual stenosis following rescue/adjunctive percutaneous coronary intervention with impaired myocardial perfusion and adverse outcomes among ST-segment elevation myocardial infarction patients.
OBJECTIVES We hypothesized that <0% residual stenosis (RS) after rescue/adjunctive percutaneous coronary intervention (PCI) following fibrinolytic administration in ST-segment elevation myocardial infarction (STEMI) would be associated with improved outcomes. BACKGROUND Prior studies have associated larger lumen diameters after PCI with reduced rates of restenosis and target vessel revascular...
متن کاملAssociation of duration of symptoms at presentation with angiographic and clinical outcomes after fibrinolytic therapy in patients with ST-segment elevation myocardial infarction.
OBJECTIVES We sought to determine if an underlying mechanism of the association between prolonged symptom-to-treatment times and adverse outcomes may be an association of symptom-to-treatment times with impaired Thrombolysis In Myocardial Infarction myocardial perfusion grades (TMPGs). BACKGROUND Prolonged symptom duration among ST-segment elevation myocardial infarction (STEMI) patients unde...
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ورودعنوان ژورنال:
- The American journal of cardiology
دوره 94 2 شماره
صفحات -
تاریخ انتشار 2004